Ksenija Radotić Hadži-Manić - Универзитет у Београду – Институт за мултидисциплинарна истраживања

Ksenija Radotić Hadži-Manić

PhD in Biological sciences

Research professor

Department of Life Sciences

Address: Bulevar despota Stefana 142, 11060 Belgrade

Telephone: (+381) 11 2078 400

E-Mail:

xenia@imsi.bg.ac.rs

Links:

ORCID ID: 0000-0002-9770-0788

ResearchGate: https://www.researchgate.net/profile/Ksenija_Radotic

Research area

Secondary plant metabolism in response to stress
Design, synthesis and application of new materials based on plant cell walls
Synthesis and characterization of nanoparticles and study of their biological effects
Development of optical spectroscopy methods application (fluorescent, infrared) in analytical and diagnostic studies of plant / animal systems and food

Skills

Spectrofluorimeter and phosphorimeter, spectrophotometer; extraction methods from plant tissues, measurements of enzyme activities and small molecules content by spectrophotometry and spectrofluorimetry.

Project coordination and management; Lectures to students (Molecular biophysics, Systems biophysics, Ecobiophysics)

Biography
Projects
Selected publications

Work experience:

2004-present: Principal Research Fellow, Institute for Multidisciplinary Research, University of Belgrade, Serbia.
1999-2004: Senior Research Fellow (Research Associate Professor), Centre for Multidisciplinary Studies, University of Belgrade, Serbia.
1995-1999: Research Fellow (Research Assistant Professor), Centre for Multidisciplinary Studies, University of Belgrade, Serbia.
1990-1995: Research Assistant, Centre for Multidisciplinary Studies, University of Belgrade, Serbia.

Education:

1994: Ph.D. in Plant biophysics and biochemistry, Faculty of Biology, University of Belgrade.
1990: M.Sc. in Biophysics, Faculty of Biology, University of Belgrade.
1986: B.Sc. in Molecular Biology and Physiology, Faculty of Biology, University of Belgrade.

Awards and certificates:

2011 Honor for teaching at all academic levels at the Faculty of Biology, University of Belgrade
2012 Grant for sabbatical, institute Scion, Rotorua, New Zealand
2012, 2014 Fellowship at the Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Other professional activities

Patent applications:

P-2021/0073 Use of non-toxic organic nanoparticles to increase productivity of cultivated plants and the procedure of their application
PCT/RS2021/000017 Synthesized lignin oligomers, method of obtaining and use thereof

2017- 2021: Member of the IUPAB (International Union for Pure and Applied Biophysics) Council
2019- present: President of the Serbian Biophysical Society
2007-2010: Member of the Parental Scientific Committee for Biology in the Ministry of Education, Science and Technological Development, Serbia
2007: Participation in the organization of the Regional Biophysical Conference in Lake Balaton, Hungary
2012: Participation in the organization of the Regional Biophysical Conference in Kladovo, Serbia.
2018: Participation in the organization of the International Biophysical School “Academician Radoslav Andjus”: Mechanobiology in Kotor, Montenegro.

Courses taught:

2012-present: Lectures in Molecular biophysics and Ecobiophysics, Studies at the University of Belgrade.
1995-2010: Lectures in Molecular and membrane biophysics, Faculty of Biology (undergraduate and postgraduate studies) and Centre for Multidisciplinary Studies (postgraduate studies), University of Belgrade, Serbia.
2000-2002: Lectures in Systems biophysics, Faculty of Biology (undergraduate studies), University of Belgrade, Serbia.

Editorial and Reviewer’s activity (journals, books, projects):

Member of editorial boards of the FOODS (MDPI) and European Biophysical Journal
Reviewer for the journals: Journal of Trace Elements in Medicine and Biology, Chemosphere, Analytical chemistry insights, Colloids Surfaces B: Biointerfaces, Scientific Reviewes, European Biophysical Journal, Analyst, Bioresources, Journal of Colloid and Interface Sciences.
Reviewer of the series of university textbooks “General Physiology and Biophysics” by Professor Radoslav Andjus (Professor of Physiology and Biophysics at the University of Belgrade and a member of SANU): “Ionic Channels” (2001, ISBN 86-80109-08-8), “Sensory Receptors” (2001 , ISBN 86-80109-09-6), “Neurobiophysics” (2002, 86-80109-10-X), “Principles of System Analysis” (2006, 86-80109-11-8).
Project review: 2007 – at the invitation of the Chilean Research Fund Council (FONDECYT) and 2019 – at the invitation of the Ministry of Education, Science and Technological Development of the Republic of Serbia

Memberships:

Biophysical society of Serbia (President), Society of physical chemistry of Serbia, Society for plant physiology of Serbia, International union for pure and applied biophysics, European biophysical society, International bryozoan association.

Current:

2021-2025 (May) „Multifunctional Hybrid 2D Nanomaterials for Their Therapeutic Application”, Reference: MCIN/AEIJ10.13039/501100011033) PID2021-1226130B-IOOCall for “Knowledge Generation Projects”, of the Ministry of Science and Innovation/State Research Agency of Spain.

Past:

Domestic

2001-2005 “Cellular response to pollution stress in trees. Possibility of application in monitoring of the environment”

2006-2010 “Investigation of novel biosensors for plant monitoring and diagnostics”

2011-2019 “Study of structure-function relationships in the plant cell wall and modifications of the wall structure by enzyme engineering”

2011-2019 “Synthesis, processing and characterisation of nanostructural materials for application in energetics, mechanical engineering, environmental protection and biomedicine-SUBPROJECT: Study and modifications of the structure of plant cell wall as a basis of the new materials for nanotechnology applications“

2019-2020 “Hydrogels with synthesized lignin oligomers as antimicrobial substances and wound healing agents” – funded by the Innovation fund of the Republic of Serbia and Technology Transfer Center of the University of Belgrade

2020-2021 “Nanobionic stimulation of agricultural plant productivity”- funded by the Innovation Fund of the Republic of Serbia within the call Proof of Concept

2024-2025 “Innovative lignin nanoparticles based bio-bactericide for agricultural application”, Proof of Concept within Saige project

International

2001, 2002 “Infrared microspectrometry of the plant cell walls”, LURE, Orsay, France (PI)

2001: “Fluorescence lifetime and spectra of lignin and related compounds”, LURE, Orsay, France (PI)

2004-2005 “New methods for the investigation of the structure of plant cell walls” France-Serbia bilateral project with Laboratory for the cellular biology from Versailles, France,

2010-1012 “Structural anisotropy of the plant cell walls of various origin and their constituent polymers, using DP-LSM“ Hungary/Serbia bilateral project with the Institute of Plant Biology, Biological Research Center, Hungary Academy of Sciences, Szeged, Hungary

2014-2016 „Advanced image analysis at the micron scale in biology and medicine“ Belarus/Serbia bilateral project with United Institute of Informatics Problems of the National Academy of Sciences of Belarus, Minsk, Belarus

COST actions (European cooperation in science and technology) 2008-2012 COST FP0802 „Experimental and computational microcharacterization techniques in wood mechanics“ (MC member)

2016 “Synchrotron based FTIR micro-spectroscopy on structural and chemical transformations in maize cell wall after Mn stress”, Synchrotron ALBA, MIRAS BL01, 2016091816 (PI)

2017 “Subcellular characterization of organic carbon dots in maize root after copper stress: synchrotron based FTIR micro-spectroscopy study, Synchrotron ALBA, MIRAS BL01, 2017032156

2018 “Subcellular characterization of adenocarcinoma human cells treated with organic carbon dots as drug delivery agent by synchrotron based FTIR micro-spectroscopy study”, Synchrotron ALBA, MIRAS BL01, 2018022774 (PI)

2019-2021 “Microstructural and mechanical characteristics of concrete with the addition of renewable materials – a bilateral project between Serbia and Croatia, funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia and the relevant body in the Republic of Croatia

COST actions (European cooperation in science and technology) (PI)

2017-2021 CA16101 “Multi-modal imaging of forensic science evidence – tools for forensic science “ (MC member)2019-2023 CA18237 “European Soil-Biology Data Warehouse for Soil Protection” (EUdaphobase)

2022 „Subcellular anticancer effects of N,S-carbon dots@Metal-Organic Frameworks complex with focus on protein aggregation in breast cancer cells sensitive and resistant to anti-estrogen drugs by synchrotron based FTIR micro-spectroscopy study“, Synchrotron ALBA, MIRAS BL01, 2022025618 (PI)

2025 „”A novel lignin nanoparticles’ poloxamer composite for ocular treatments: evaluation on cellular level by synchrotron FTIR micro-spectroscopy”, Synchrotron ALBA, MIRAS BL01, 2024098663 (PI)

Milenković I., Zhou Y. Q., Borišev M., Serafim L. F., Chen J. Y., ElMetwally A. E., Spasić S. Z., Algarra M., Yuso M. V. M., Prabhakar R., Leblanc R. M., Radotić K. (2024) Modeling of orange carbon dots-CO₂ interaction and its effects on photosynthesis and productivity in maize and green beans. Journal of Environmental Informatics: 43, 80
Spasojević, D., Zmejkoski, D., Matić, N.M., Krnjaić D., Radotić K. (2024) Therapeutic potential of low-molecular weight lignin model polymer fractions for treating skin lesions in animals: a pilot study. Vet Res Commun 48, 591.
Radotić K., Melø T. B., Lindgren M. (2023) A fluorescence spectroscopic study of light transmission and adaxial-abaxial distribution of emitting compounds in leaves of Christmas star (Euphorbia pulcherrima), Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 303: 123269.
Radotić K, Stanković M, Bartolić D, Natić M. (2023) Intrinsic Fluorescence Markers for Food Characteristics, Shelf Life, and Safety Estimation: Advanced Analytical Approach. Foods.; 12(16):3023. https://doi.org/10.3390/foods12163023
Bartolić, D., Mutavdžić, D., Carstensen, J.M., Stanković S., Nikolić M., Krstović S., Radotić K. (2022) Fluorescence spectroscopy and multispectral imaging for fingerprinting of aflatoxin-B1 contaminated (Zea mays L.) seeds: a preliminary study. Scientific Reports 12, 4849.
Dučić T., Milenković I., Mutavdžić D., Nikolić M., Martínez de Yuso M. V., Vučinić Ž., Algarra M., Radotić K. (2021) Estimation of carbon dots amelioration of copper toxicity in maize studied by synchrotron radiation-FTIR. Colloids and Surfaces B: Biointerfaces 204: 111828.
Milenković I., Borišev M., Zhou Y., SpasićS.Z., Leblanc R.M., Radotić K. (2021) Photosynthesis enhancement in maize via nontoxic orange carbon dots. Journal of Agricultural and Food Chemistry: 69, 5446.
Mitrović A. Lj., Simonović Radosavljević J., Prokopijević M., Spasojević D., Kovačević J., Prodanović O., Todorović B., Matović B., Stanković M., Maksimović V., Mutavdžić D., Skočić M., Pešić M., Prokić Lj., Radotić K. (2021) Cell wall response to UV radiation in needles of Picea omorika. Plant Physiology and Biochemistry 161: 176.
Simonović Radosavljević, J., Bogdanović Pristov, J., Lj. Mitrović, A., Steinbach G., Mouille G., Tufegdžić S., Maksimović V., Mutavdžić D., Janošević D., Vuković M., Garab G., Radotić K. (2017) Parenchyma cell wall structure in twining stem of Dioscorea balcanica. Cellulose 24: 4653.
Spasojević D., Zmejkoski D, Glamočlijac J., Nikolić M., Soković M., Milošević V., Jarić I., Stojanović M., Marinković E., Barisani-Asenbauer T., Prodanović R., Jovanović M., Radotić K. (2016) Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. International Journal of Antimicrobial Agents 48: 732

University of Belgrade - Institute for Multidisciplinary Research

Research area

Skills