University of Belgrade

Institute for
Multidisciplinary Research

Project information

COST Action BM1405: Non-globular proteins. From sequence to structure, function and application in molecular physiopathology.

Back
Project ID COST Action BM1405
Project Title COST Action BM1405: Non-globular proteins. From sequence to structure, function and application in molecular physiopathology.

Project Leader NGP-NET
IMSI Status Participates

Financial Source COST (European Cooperation in Science and Technology)


Category of Project COST actions

 

PROJECT DESCRIPTION

Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40% of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study. This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.


PROJECT DURATION

 

From: 26.03.2015.   To: 25.03.2019.

 

PARTNERS

 

►Austria, Belgium, BIH, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Ireland, Israel, Italy, Latvia, Lithuania, Norway, Poland, Portugal, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, UK

 

PARTICIPANTS


No. Participant Institution